| Autor: |
K. Velen, T-A. Nguyen, C. D. Pham, H. T. Le, H. B. Nguyen, B. T. Dao, T. V. Nguyen, N. T. Nguyen, N. V. Nguyen, G. J. Fox |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
The International Journal of Tuberculosis and Lung Disease. 27:322-328 |
| ISSN: |
1027-3719 |
| DOI: |
10.5588/ijtld.22.0500 |
| Popis: |
BACKGROUND: TB control remains a serious public health problem, compounded by poor treatment adherence, which increases the likelihood of onward transmission. We evaluated the effectiveness of medication event reminder monitoring (MERM) upon treatment adherence in a high TB burden setting.METHODS: We conducted an open-label parallel group randomised controlled trial among pulmonary TB adults. Participants were provided with a MERM device to store their medications. In the intervention arm, the devices were set to provide daily medication intake reminders. Primary outcome was the proportion of patient-months in which at least 6/30 doses were missed. Secondary outcomes included 1) the proportion of patient-months in which at least 14/30 doses were missed, and 2) the proportion of doses missed.RESULTS: Of 2,142 patients screened, 798 (37.3%) met the inclusion criteria and 250 participants were enrolled. The mean ratio (MR) for poor adherence between the intervention and control groups was 0.72 (95% CI 0.55–0.86). The intervention was also associated with a reduction in the proportion of patients missing at least 14/30 doses (MR 0.61, 95% CI 0.54–0.68) and the percentage of total doses missed (MR 0.75, 95% CI 0.68–0.80).CONCLUSION: MERM is effective in improving TB treatment adherence in a resource-limited environment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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