Molecular Interaction of Nonsteroidal Compounds with Uterine Progesterone Receptor (Part I)1)
| Autor: | Amiya P. Bhaduri, Anila Agnihotri, M. Seth, Avanish Kumar Srivastava, Kamboj Vp, Neelima, Shri Niwas, S. Kumar, Bhima Bhat |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Lagomorpha biology Liaison Endocrinology Diabetes and Metabolism Uterus General Medicine biology.organism_classification Molecular biology In vitro Progesterone Antagonist Cytosol Endocrinology medicine.anatomical_structure Internal medicine Progesterone receptor Internal Medicine medicine Receptor |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 88:185-192 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | Progesterone-receptor binding affinity of some nonsteroidal molecules was assessed by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of 40 compounds belonging to 5 different series tested, 3-(p-anisoyl)-2-chloro-6, 7-dimethoxy-quinoline exhibited around 50% inhibition whereas 2-(p-anisoyl) naphthalene and 3-substituted phenyl-1-(3-(2-chloro-6, 7-dialkoxy) quinolinyl)prop-2-en-1-one showed around 20% inhibition in 3H-progesterone binding for rabbit and human uterine progesterone receptor. |
| Databáze: | OpenAIRE |
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