Fusion and scission of membranes: Ubiquitous topological transformations in cells
| Autor: | Noboru Mizushima, Roland L. Knorr, Rumiana Dimova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fusion Membrane lipids Lipid bilayer fusion Cell Biology Biology Topology Biochemistry humanities Cell membrane 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Membrane medicine.anatomical_structure Membrane protein Structural Biology Genetics medicine Invariant (mathematics) Lipid bilayer Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Traffic. 18:758-761 |
| ISSN: | 1398-9219 |
| Popis: | The 2016 Nobel Prizes were awarded to Yoshinori Ohsumi for autophagy and to David Thouless, Duncan Haldane and Michael Kosterlitz for topological transitions. Both of these phenomena are intrinsically related when it comes to membranes. Here, we give a brief account on topological transformations of lipid membranes, commonly known as membrane fusion and membrane scission, and introduce the underlying topological invariant, the genus. The genus of a shape is a useful concept to distinguish unambiguously the processes of membrane fusion/scission and offers a simple method to describe complex, cellular membrane structures, such as fenestrated cristae. We distinguish and highlight the connection between topological transformations of lipid membranes and the recent awards, and point out the extraordinarily large number of topological changes during autophagy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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