Does obstructive sleep apnoea influence BNP concentrations in atrial fibrillation patients?
| Autor: | Alicja Dudzik-Plocica, Dariusz Gorko, Karolina Semczuk, Anna Rys, Anna E. Płatek, Filip M. Szymański, Krzysztof J. Filipiak, Marcin Kotkowski |
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| Rok vydání: | 2015 |
| Předmět: |
Neck circumference
medicine.medical_specialty business.industry medicine.drug_class Endocrinology Diabetes and Metabolism Atrial fibrillation Heart wall medicine.disease nervous system diseases respiratory tract diseases stomatognathic system Internal medicine Heart failure Internal Medicine Cardiology Natriuretic peptide Medicine Population study Biomarker (medicine) Sleep study Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arterial Hypertension. 19:179-186 |
| ISSN: | 2449-6162 2449-6170 |
| DOI: | 10.5603/ah.2015.0022 |
| Popis: | Background B-type natriuretic peptide (BNP) is a biomarker commonly used in diagnosing and assessing prognosis in heart failure patients. Its concentration can be elevated in various conditions associated with excessive heart wall stretch including atrial fibrillation and obstructive sleep apnoea (OSA). The aim of the study was to assess if BNP levels in atrial fibrillation patients are associated with the value of apnoea-hypopnea index (AHI). Material and methods Study population were consecutive patients with atrial fibrillation, who underwent overnight sleep study, and had blood taken for BNP concentration assessment. Subsequently, patients were divided into group according to AHI: Group I ( 15/h). Results Analysis covered 158 patients (males, 64.6%; mean age, 58.3 ± 9.2 years). 83 (52.5%) patients had AHI 15 (104.0 ± 150.8 pg/mL; p for trend = 0.03). Conclusions Majority of patients with atrial fibrillation have AHI < 5/h and these generally have lower BMI, and neck circumference. Patients who have AHI exceeding ≥ 5/h BNP levels tend to be elevated, and its values rise along with AHI. |
| Databáze: | OpenAIRE |
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