Evaluation of apparent fracture toughness of articular cartilage and hydrogels
| Autor: | Michael S. Detamore, Elizabeth A. Friis, Yinghua Xiao, Stevin H. Gehrke, Deena A. Rennerfeldt |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Toughness
Materials science Cartilage technology industry and agriculture Biomedical Engineering Medicine (miscellaneous) Mechanical failure Articular cartilage 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Cartilage tissue engineering 0104 chemical sciences Biomaterials Fracture toughness medicine.anatomical_structure Self-healing hydrogels medicine 0210 nano-technology Biomedical engineering Tensile testing |
| Zdroj: | Journal of Tissue Engineering and Regenerative Medicine. 11:121-128 |
| ISSN: | 1932-6254 |
| Popis: | Recently, biomaterials-based tissue-engineering strategies, including the use of hydrogels, have offered great promise for repairing articular cartilage. Mechanical failure testing in outcome analyses is of crucial clinical importance to the success of engineered constructs. Interpenetrating networks (IPNs) are gaining more attention, due to their superior mechanical integrity. This study provided a combination testing method of apparent fracture toughness, which was applied to both articular cartilage and hydrogels. The apparent fracture toughnesses of two groups, hydrogels and articular cartilage, were evaluated based on the modified single-edge notch test and ASTM standards on the single-edge notch test and compact tension test. The results demonstrated that the toughness for articular cartilage (348 ± 43 MPa/mm½ ) was much higher than that for hydrogels. With a toughness value of 10.8 ± 1.4 MPa/mm½ , IPNs of agarose and poly(ethylene glycol) diacrylate (PEG-DA) looked promising. The IPNs were 1.4 times tougher than PEG-DA alone, although still over an order of magnitude less tough than cartilage. A new method was developed to evaluate hydrogels and cartilage in a manner that enabled a more relevant direct comparison for fracture testing of hydrogels for cartilage tissue engineering. Moreover, a target toughness value for cartilage of using this direct comparison method has been identified (348 ± 43 MPa/mm½ ), and the toughness discrepancy to be overcome between hydrogels and cartilage has been quantified. Copyright © 2014 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|