Effectiveness of wound healing using the novel collagen dermal substitute INSUREGRAF®
| Autor: | Dohern Kym, Haejun Yim, June-Bum Kim, GeunHyung Kim, Samhyun Jung, Sunghee Yang, Yong Suk Cho, Wook Chun, Hyeon Yoon, Hyeong Tae Yang, Eunkyung Yang, Jun Hur |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
integumentary system Biocompatibility Chemistry General Chemical Engineering 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology 03 medical and health sciences 030104 developmental biology Collagen sponge Skin tissue In vivo Skin substitutes 0210 nano-technology Wound healing Single layer Biomedical engineering |
| Zdroj: | RSC Advances. 6:59692-59701 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c5ra27423k |
| Popis: | Collagen sponges are often used as dermal substitutes in the treatment of burns, trauma, infections, and wounds. Dermal substitutes that can be applied in a one-stage operation are particularly important for dermal regeneration. Some protocols for the production of collagen sponges have been developed, but many issues remain, including low yield, contraction, and expense. In this study, the effectiveness of two skin substitutes was evaluated. Specifically, we compared two thin matrices, i.e., the newly developed INSUREGRAF® 1.2 mm and the widely used Matriderm® 1 mm Single Layer, with respect to their biochemical and mechanical properties, safety, and efficacy. We examined the rate of contractibility and biocompatibility using in vitro and in vivo models. The INSUREGRAF had an interconnected pore structure, which affects cell attachment and proper vascularization. Accordingly, this novel collagen sponge type has the potential to promote skin tissue regeneration and is especially suitable for full-thickness skin defects as a one-stage operation substitute. |
| Databáze: | OpenAIRE |
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