The Pharmacology and Clinical Pharmacology of Defibrotide: A New Profibrinolytic, Antithrombotic and Anti-Platelet Substance

Autor:	Y. Özsoy, S Balkuv-Ulutin, O. N. Ulutin, G Cizmeci, Turgut Ulutin, M. S. Ugur
Rok vydání:	1990
Předmět:	Clinical pharmacology Chemistry medicine.medical_treatment Heparin Defibrotide Pharmacology law.invention Endothelial stem cell law Antithrombotic Fibrinolysis medicine Platelet Protein C medicine.drug
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781461366973
DOI:	10.1007/978-1-4615-3806-6_46
Popis:	Defibrotide, a deoxypolyribonuclide, has been found to modulate endothelial cell function causing increase in t-PA and decrease in PAI levels and also increase in PGI2 production. In addition, it increases platelet c-AMP levels and decreases MDA and TXB2 formation in human. Defibrotide inhibits platelet aggregate formation in vitro experiments as well as end-to-end anostomosis in rats. So, defibrotide inhibits the activation of platelets. Besides an increase of protein C and S levels a synergic action of heparin was observed in animal experiments. A strong antithrombotic effect has been observed in animal models.
Databáze:	OpenAIRE
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