| Autor: |
Kenji Takagishi, Kimihiko Takeuchi, Kazuhiko Inoue, Tatsuya Takemura, Katsuaki Kanbe |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
APLAR Journal of Rheumatology. 8:213-219 |
| ISSN: |
1479-8077 |
| Popis: |
Aims: The aim of this study was to determine which matrix metalloproteinases (MMPs) are involved with C-reactive protein (CRP) and which stage of rheumatoid arthritis (RA) correlated with MMP-9 or MMP-13 level. Methods: In the present clinical trial, we analysed MMP-9 activity and MMP-13 activity in 53 RA patients. We examined the presence of MMP-9 and MMP-13 in the synovium tissue and articular cartilage in RA patients by immunohistochemistry. In addition, we compared these factors and clinical Steinbrocker staging. Results: We found that MMP-9 in blood serum correlates significantly with CRP. MMP-13 also correlates with CRP but the coefficiency with CRP is much higher in MMP-9 (r = 0.6694) than in MMP-13 (r = 0.4037). MMP-9 and MMP-13 did not correlated with rheumatoid factor (RF). MMP-9 level is increased in stages II and III in RA. On the other hand, MMP-13 is increased in stages III and IV. Our results indicated that early stage RA shows high MMP-9 release in serum while late stage RA shows high MMP-13 release. Conclusion: MMP-9 activity may correlate with synovium proliferation with vascularization, and serum MMP-13 activity may correlate with the grade of joint destruction in rheumatoid arthritis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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