Modeling-Based Approach towards On-Scale Implementation of a Methanethiol-Emitting Reaction

Autor:	Lindsay A. Hobson, Olav Lyngberg, Brenda Remy, Dong Lin, Shawn Brueggemeier, Alexander J. Marchut
Rok vydání:	2008
Předmět:	Wet scrubber chemistry.chemical_compound Pilot plant Chemical engineering Chemistry Sodium hydroxide Scientific method Sodium hypochlorite Organic Chemistry Methanethiol Physical and Theoretical Chemistry Kinetic energy Volumetric flow rate
Zdroj:	Organic Process Research & Development. 12:381-391
ISSN:	1520-586X 1083-6160
Popis:	Utilizing kinetic process modeling, the conditions for a pharmaceutical guanylation reaction were optimized to promote controlled generation of methanethiol and efficient removal from the off-gas stream via wet scrubbing. Optimization of the kinetic model identified two guanylation reaction temperature profiles that reduced the maximum off-gas flow rate by approximately 75% while increasing the reaction cycle time by only 15−23%. The identified reaction conditions were quickly verified in laboratory-scale experiments and implemented in the scale-up of this process from kilo laboratory to pilot plant scale. Additionally, computational fluid dynamics calculations of the sodium hypochlorite and sodium hydroxide wet scrubber were used to demonstrate that methanethiol oxidation within the wet scrubber was rapid. Within this system, methanethiol bubbles were only expected to travel approximately 40 mm before being completely oxidized. Upon scale-up, the process-modeling-based approach described here provided me...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::efa66cf25d74d50c8cb55449527c96d6 https://doi.org/10.1021/op7002166 Zobrazit plný text záznamu