Relationship between prolongation of antiinflammatory activity of hydrocortisone incorporated into liposomes and their lipid composition in experimental arthritis
| Autor: | E. F. Davidenkova, L. A. Noskin, L. V. Loshakova, N. K. Ternova, O. A. Rozenberg, Yu. A. Sulimenko, N. N. Likhosherst |
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| Rok vydání: | 1984 |
| Předmět: |
Liposome
Chemistry medicine.medical_treatment Intraperitoneal injection Arthritis hemic and immune systems chemical and pharmacologic phenomena General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Cytolysis CTL Splenocyte medicine Cytotoxic T cell Hydrocortisone medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 97:716-718 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The effect of intraperitoneal injection of beta-carotene in different doses on the formation of cytolytic T lymphocytes (CTL) in a one-way mixed lymphocyte culture (MLC) of allogeneic mice was studied. The maximal cytotoxic activity of lymphocytes was attained in the MLC with splenocytes of mice which received 10 mg/kg beta-carotene 6 days before experimentation. The correlation was studied between the beta-carotene ability to stimulate CTL formation and antineoplastic activity. It was discovered that injection of beta-carotene in doses and times provoking maximal CTL induction had no effect on the animals' lifespan and the size of transplanted sarcoma 180. |
| Databáze: | OpenAIRE |
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