ChemInform Abstract: trans-1,3-Dithiane-1,3-dioxide, a New Chiral Acyl Anion Equivalent for the Preparation of Masked Activated Acids: Application to the Synthesis of α-Hydroxy Acid Derivatives

Autor:	Varinder K. Aggarwal, Andrew Peter Thomas, Richard J. Franklin
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Pummerer rearrangement Moiety General Medicine Medicinal chemistry Dithiane Ion
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199449141
Popis:	trans-1,3-Dithiane-1,3-dioxide reacts with high diastereoselectivity with aromatic aldehydes and the 1,3-dithiane-1,3-dioxide moiety can be easily converted to a thiolester without racemisation by carrying out a Pummerer reaction; the thiolester is a group that can be readily transformed into acids, esters, amides, ketones and aldehydes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::efa3a34e8e1b9b47ef56fe28e70448e9 https://doi.org/10.1002/chin.199449141 Zobrazit plný text záznamu Plný text