Impact of organ confined prostate cancer treatment on quality of life
| Autor: | M.T. Marquez-Sanchez, J.A. Mirón-Canelo, Barbara-Yolanda Padilla-Fernandez, J.L. Alvarez-Ossorio-Fernandez, F. Miglioni, C.A. Muller-Arteaga, María Fernanda Lorenzo-Gómez, María-Carmen Flores-Fraile, N.A. Linares-Mesa, María-Begoña García-Cenador, A. Alvarez-Ossorio-Rodal, S. Valverde-Martínez |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Prostatectomy business.industry medicine.medical_treatment Incidence (epidemiology) Brachytherapy 030232 urology & nephrology Cancer Urinary incontinence General Medicine medicine.disease 03 medical and health sciences Prostate-specific antigen Prostate cancer 0302 clinical medicine Quality of life Internal medicine medicine medicine.symptom business |
| Zdroj: | Actas Urológicas Españolas (English Edition). 44:630-636 |
| ISSN: | 2173-5786 |
| DOI: | 10.1016/j.acuroe.2020.10.001 |
| Popis: | Introduction Prostate cancer (PCa) is the second most common male cancer in the world. Its incidence is estimated to grow to 1.7 million new cases and 499,000 new deaths by 2030. Treatment of OCPC can affect patients physically and mentally, as well as their close relationships and their job or career, which conditions health-related quality of life (QoL). Objective Evaluate the impact on QoL attributable to the treatment for Organ Confined Prostate Cancer (OCPC). Materials and methods Prospective multicenter observational study of 406 patients with OCPC treated from January 2015 to June 2018. The sample was divided into four study groups, according to the type of treatment: radical prostatectomy (RP) (GA), external radiotherapy (ERT) (GB), brachytherapy (BT) (GC) and other treatments different from monotherapy with RP, ERT or BT (GD). Results The age in GC was lower, the mean Prostate Specific Antigen (PSA) of all patients was 8.13 ng/ml, the group with the highest mean PSA was GB with a mean of 10.43 ng/dL, the mean Tumor Stage (TNM) was 3.82, and GD had the lowest post treatment quality of life. Conclusion OCPC treatment affects QoL. Curative monotherapies, specifically RP and BT, have less effect on QoL than external radiotherapy or other therapeutic alternatives. Urinary incontinence and fistulas secondary to OCPC have the highest impact on QOL impairment. The internationally validated SF 36 questionnaire is a useful cross-sectional measure of QOL to compare the impact of OCPC treatment modalities. |
| Databáze: | OpenAIRE |
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