| Popis: |
Summary Historically, cancer has been the major therapeutic focus for PDT. The growing understanding of how PDT affects the behavior and viability of a variety of cell types has fostered the evaluation and use of PDT for non-oncologic indications, including ocular, cardiovascular, and immune diseases. The formulation, pharmacokinetics, and type of photosensitizer, the duration between its administration and light application, and the region of PDT on immune reactions. Among immune-mediated diseases, psoriasis is a promising candidate indication for PDT, since the skin lesions and the immunocytes associated with active disease are readily accessible to activating light. The beneficial effect of PDT on psoriasis may arise from a reduction in the number of pathogenic T cells, a modification of APC function, and/or an alteration of keratinocyte cytokine production within afflicted skin. Continued efforts to optimize PDT regimens will reveal the ultimate potential of this technique to effectively treat immune-mediated diseases. Likewise, there is potential to exploit the capacity of PDT to stimulate anti-tumor immunity. Both of these therapeutic areas will continue to provide opportunities to understand the underlying biological processes and develop improved treatment regimens. |
