Night/Day Changes in Pineal Expression of >600 Genes

Autor: Qiong Shi, Fabrice Morin, Ann Humphries, Morten Møller, Michael J. Bailey, David Allan Carter, Joan L. Weller, David Sugden, Peter J. Munson, Jong-So Kim, Pascaline Gaildrat, David C. Klein, Steven L. Coon, John B. Hogenesch, Martin F. Rath, Surajit Ganguly, Zoila G. Rangel, Ruben Baler
Rok vydání: 2009
Předmět:
Zdroj: Journal of Biological Chemistry. 284:7606-7622
ISSN: 0021-9258
DOI: 10.1074/jbc.m808394200
Popis: The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip® technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate
Databáze: OpenAIRE