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SUMMARY Control oftissue optical properties is important for development ofoptical tomography, photodynamic therapyand selective photodamage of tissue components. As a scattering medium, tissue shows optical effects that arecharacteristic for turbid optical systems. Administration of the appropriate chemical agents, like solutions of glucose,glycerol,propylene glycol, etc. can effectively change scattering properties of a living tissue.1Control of skin optical properties was related to the immersion of refractive indices of scatterers and groundmatter. Skin optical properties in general are defined by dermis because of relatively big thickness of dermis (95% ofthe human skin). The dermis consists mainly of network of collagen fibers, elastic fibers, and an interstitial substanceconsisting of proteoglycans, salts, and water. Refractive indices of skin components differ from that of interstitialmaterial. The variation in refractive index causes light scattering that decreases light penetration into a tissue.Osmotic active agents (glucose, dimethyl sulfoxide, trasograph, verografin, glycerol, propilene glycol, etc.)have refractive indices higher than interstitial matter and can be used to reduce the scattering in tissues. Tissue — |
