| Popis: |
The transcription activator, Interferon regulatory factor-1 (IRF-1), has been shown to function as a tumor suppressor and the structurally related interferon regulatory factor-2 (IRF-2) as a counterpart. The loss of IRF-1 function or overexpression of IRF-2 are possible mechanisms of cancer development. In the present study, IRF-1 and IRF-2 gene expression was analyzed in human hepatoma cell lines (HuH7, huH 1, HepG2 and PLC/PRF/5) and the normal liver. We found a small amount of exon-skipped IRF-1 mRNA in HuH7 and huH 1, and the low level of IRF-1 mRNA in PLC/PRF/5, but we could not find the overexpression of IRF-2 mRNA in any hepatoma cells lines. Thus, it is possible that hepatocarcinogenesis involves some alterations in expression of IRF-1 gene. |
