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Department of Chemistry, Faculty of Science, Northern Border University, Arar, Saudi ArabiaReceived August 26, 2011, Accepted October 3, 2 011A number of new 2,5-disubstituted 1,3,4-thiadiazole and their S- or N-substituted derivatives as well as thecorresponding sugar hydrazone derivatives were synthesized and tested for their antimicrobial activity againstBacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actino-mycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.Key Words : 1,3,4-Thiadiazole, Sugar hydrazones, Antimicrobial activityIntroductionThe problem of multi-drug resistant microorganisms hasreached on alarming level around the world and for thetreatment of microbial infections; the synthesis of new anti-infectious compounds has become an urgent need. 1,3,4-Thiadiazole ring containing compounds represent an im-portant class of heterocyclic nitrogen compounds and theirderivatives are characterized with a broad spectrum ofbiological activity in both agrochemical and pharmaceuticalfields. Many 1,3,4-thiadiazoles derivatives have been usedas “privileged” scaffolds to produce substances of interest innumerous therapeutic areas, such as anti-inflammatory |
