Magnetic targeting of paclitaxel-loaded poly(lactic-co-glycolic acid)-based nanoparticles for the treatment of glioblastoma

Autor:	Lakshmi Pallavi Ganipineni, Véronique Préat, Nicolas Joudiou, Bernard Ucakar, John Bianco, Bernard Gallez, Pierre Danhier, Mengnan Zhao, Chiara Bastiancich, Fabienne Danhier
Rok vydání:	2018
Předmět:	0301 basic medicine Biodistribution medicine.medical_treatment Biophysics Pharmaceutical Science Bioengineering 02 engineering and technology Blood–brain barrier Biomaterials 03 medical and health sciences chemistry.chemical_compound In vivo Drug Discovery medicine Chemotherapy Organic Chemistry technology industry and agriculture General Medicine 021001 nanoscience & nanotechnology 3. Good health PLGA 030104 developmental biology medicine.anatomical_structure Paclitaxel chemistry Cancer research Nanocarriers 0210 nano-technology Ex vivo
Zdroj:	International Journal of Nanomedicine. 13:4509-4521
ISSN:	1178-2013
DOI:	10.2147/ijn.s165184
Popis:	Introduction Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survival rates averaging
Databáze:	OpenAIRE
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