Motor Unit Number Index (MUNIX): A Biomarker for Evaluation of Lower Motor Neuron Involvement in Amyotrophic Lateral Sclerosis
| Autor: | Anna A. Abramova, M. N. Zakharova, Amayak Broutian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry 05 social sciences Lower motor neuron involvement Motor unit number Disease Motor neuron medicine.disease 050105 experimental psychology Clinical trial 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Physical medicine and rehabilitation Physiology (medical) medicine Biomarker (medicine) 0501 psychology and cognitive sciences Motor unit number estimation Amyotrophic lateral sclerosis business 030217 neurology & neurosurgery |
| Zdroj: | Human Physiology. 46:900-911 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119720080010 |
| Popis: | Although multiple clinical trials of various therapeutic interventions in amyotrophic lateral sclerosis (ALS) have been conducted so far, most of them lack comprehensive study design due to the absence of progression biomarkers that could provide adequate understanding of the rate and pattern of disease progression. Motor unit number estimation (MUNE) methods, motor unit number index (MUNIX) in particular, could be a promising tool for evaluating progression in ALS. This paper provides an extensive review of the main aspects of current MUNIX methodology and its emerging modifications, correlations with clinical and electrodiagnostic measures, reproducibility issues, utility in motor neuron disease diagnostics, and assessment of disease progression in clinical trials. |
| Databáze: | OpenAIRE |
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