A microfluidic platform for screening and optimization of organic reactions in droplets
| Autor: | Pawel Jankowski, Rafał Kutaszewicz, Piotr Garstecki, Dominika Ogończyk |
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| Rok vydání: | 2019 |
| Předmět: |
Fluid Flow and Transfer Processes
Green chemistry Materials science 010405 organic chemistry Organic Chemistry Microfluidics Condensation Imine 010402 general chemistry 01 natural sciences Chemical reaction 0104 chemical sciences chemistry.chemical_compound Organic reaction chemistry Chemical engineering Chemistry (miscellaneous) Yield (chemistry) Reagent |
| Zdroj: | Journal of Flow Chemistry. 10:397-408 |
| ISSN: | 2063-0212 2062-249X |
| Popis: | We report an automated microfluidic system for screening and optimization of chemical reactions performed inside microliter liquid droplets. The system offers precise control over generation, merging and flow of droplet “micro-reactors” and over reaction conditions, including the volumes of the reagents, temperature and time. The high level of control coupled with the ability to quickly screen multiple reaction conditions allow us to thoroughly monitor the impact of input parameters on the yield of the reaction. In addition, the reagent consumption is kept remarkably low. As an exemplary use of our system we demonstrate a comprehensive study of acid-catalyzed (para-toluenesulfonic acid, p-TsOH) model imine formation (condensation of ortho-nitrobenzaldehyde and phenylethylamine) in an organic solvent (ethanol). By use of novel screening methods described herein, we unfold that the acid-catalyzed model imine formation in the organic medium can be considered as an assembly of acid-mediated and non-catalyzed reactions, both of which accelerate with increasing temperature. |
| Databáze: | OpenAIRE |
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