Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity

Autor:	Xizi Liu, Shiyi Han, Siyang Fan, Yinqing Li, Qian Yang
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Circular dichroism Alismataceae biology Traditional medicine Chemistry ved/biology ved/biology.organism_classification_rank.species Inhibitory postsynaptic potential biology.organism_classification Rhizome Terpene Triterpenoid Triterpene Alisma orientale
Zdroj:	Planta Medica International Open. 8:e114-e121
ISSN:	2509-6656 2509-9264
DOI:	10.1055/a-1543-1261
Popis:	The rhizome of Alisma orientale (sam.) Juz. is used in clinics for eliminating dampness, reducing edema, and promoting diuresis. This study aimed to elucidate the compounds and investigate their nuclear factor-kappa inhibitory activities in human embryonic kidney 293 cells. A new triterpene, alismaketone B (1); a new natural nortriterpene, noralisolic acid A (2); and 13 known protostane-type triterpenes were isolated from the rhizome of A. orientale. The new structures and their absolute configurations were established using HRESIMS, NMR, and electronic circular dichroism experiments. All isolated compounds were evaluated for their inhibitory activity on NF-κB. The compounds 8, 9, 10, and 14 showed moderate NF-κB inhibitory activities with their IC50 values being 64.7, 32.3, 47.3, and 37.3 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef63ed35a2da5856cc82f42fdf1f3f1c https://doi.org/10.1055/a-1543-1261 Zobrazit plný text záznamu