Thermodynamic Dissociation Constants of Alendronate and Ibandronate by Regression Analysis of Potentiometric Data

Autor:	Lucie Netolická, Milan Meloun, Zuzana Ferenčíková, Tomáš Pekárek
Rok vydání:	2011
Předmět:	Systematic error Dissociation constant Antiresorptive Drugs Chemistry General Chemical Engineering Potentiometric titration Analytical chemistry Physical chemistry Regression analysis General Chemistry
Zdroj:	Journal of Chemical & Engineering Data. 56:3848-3854
ISSN:	1520-5134 0021-9568
DOI:	10.1021/je200512e
Popis:	Mixeddissociationconstant(s)oftwonitrogen-containingbisphosphonateacidsHJL,alendronateandibandronate,at various ionic strengthsI in the range of (0.02 to 0.30) M at (298.15 and 310.15) K have been determined with the use of regression analysis of potentiometric titration data when common parameters pKa,j, J = 1, ..., J, and group parameters L0 and HT are simultaneously refined. Ibandronate and alendronate are the antiresorptive drugs most widely used to treat osteoporosis owing to theirparticularlyhighpotencyatinhibitingosteoclast-mediatedboneresorption.Externalcalibrationoftheglasselectrodecellinthe activity scale aH+ was used. The estimate of ill-conditioned group parameters has a great influence on a systematic error in the estimatedpKa,and therefore itmakes the computational strategy important.Asmoregroup parametersare refinedand abetter fitis achieved,amorereliableestimateofdissociationconstantsresults.ThethermodynamicdissociationconstantpKa wasestimatedby
Databáze:	OpenAIRE
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