The CHADS 2 and CHA 2 DS 2 -VASc scores predict atrial fibrillation in dyslipidemic individuals: Role of incorporating low high-density lipoprotein cholesterol levels
| Autor: | Evangelos Liberopoulos, Fotios Barkas, Moses Elisaf, Stavroula Tsiara, Panagiotis Korantzopoulos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Statin business.industry medicine.drug_class Cholesterol Atrial fibrillation 030204 cardiovascular system & hematology medicine.disease Predictive value Low high-density lipoprotein cholesterol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein chemistry Internal medicine parasitic diseases Cardiology medicine Physical therapy 030212 general & internal medicine Cardiology and Cardiovascular Medicine business Lipid clinic Lipoprotein cholesterol |
| Zdroj: | International Journal of Cardiology. 241:194-199 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2017.04.062 |
| Popis: | Aim To investigate the value of CHADS 2 and CHA 2 DS 2 -VASc scores in predicting atrial fibrillation (AF) among dyslipidemic individuals and assess the additional value of incorporating low levels of high-density lipoprotein cholesterol (HDL-C). Methods This observational study included 1241 individuals attending a lipid clinic. Models including clinical and laboratory parameters were constructed to test the predictive value of CHADS 2 and CHA 2 DS 2 -VASc scores as well as low HDL-C levels for incident AF. Low HDL-C levels were defined as Results After excluding 18 patients with AF at baseline, 1223 subjects were followed-up for a median period of 6years (IQR: 4–10), and 34 (2.8%) developed AF. Baseline CHADS 2 (OR: 1.71; 95% CI: 1.28–2.29, p 2 DS 2 -VASc scores (OR: 1.56; 95% CI: 1.26–1.92, p p 2 and CHA 2 DS 2 -VASc scores were significant predictors for new-onset AF (C-Statistic: CHADS 2 0.679, p 2 DS 2 -VASc 0.698, p 2 scores were associated with reduced event-free survival from AF (log-rank=10.62, p =0.001) with differences potentiated if stratified by CHA 2 DS 2 -VASc score (log-rank=22.29, p p Conclusions CHADS 2 and CHA 2 DS 2 -VASc scores predict new AF in dyslipidemic patients. Risk prediction improved modestly when low HDL-C levels were included. |
| Databáze: | OpenAIRE |
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