ChemInform Abstract: Synthesis, DNA-Damaging and Cytotoxic Properties of Novel Topoisomerase II-Directed Bisantrene Analogues

Autor:	Ambrogio Oliva, Manlio Palumbo, Fulvio Guano, Giovanni Capranico, Ernesto Menta, Giuseppe Zagotto
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Anthracene biology Stereochemistry Topoisomerase Hydrazone General Medicine Ring (chemistry) chemistry.chemical_compound chemistry biology.protein Side chain Cytotoxic T cell Bisantrene Cytotoxicity
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199818119
Popis:	New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally isomeric drugs modulates topoisomerase II poisoning and specificity, along with cytotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef5cc5c6cd38827953e3fa74b8ee16ed https://doi.org/10.1002/chin.199818119 Zobrazit plný text záznamu Plný text