Regulatory T cells control CNS-infiltration of autoreactive T cells during viral infection without affecting the antiviral immune response (83.24)
| Autor: | Luisa Cervantes-Barragan, Sonja Firner, Roland Züst, Carolin Prodinger, Ingo Bechmann, Tim Sparwasser, Volker Thiel, Burkhard Ludewig |
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| Rok vydání: | 2010 |
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| Zdroj: | The Journal of Immunology. 184:83.24-83.24 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.184.supp.83.24 |
| Popis: | Regulatory T cells are essential for suppressing immune responses to autoantigens and therefore help to prevent autoimmunity. During viral infections in the CNS, an indiscriminate regulation of T cells can prevent autoimmune diseases but could also impair the control of viral replication. We analyzed here the impact of regulatory T cells in the control of T cell infiltration to the CNS, virus-induced CNS pathology, and viral clearance using the mouse hepatitis virus (MHV) A59 intranasal infection model; a virus infection that leads to encephalitis and demyelination. MHV infection of “depletion of regulatory T cell” (DEREG) mice, revealed that the lack of regulatory T cells during MHV infection leads to an increased T cell infiltration and pathology in the CNS. However, antiviral T cells response were not affected by the depletion of FoxP3+CD4+ T cells indicating that regulatory T cells control infiltration of T cells to the CNS without impairing or delaying the antiviral immune response. Moreover, in MHV infected mice, adoptively transferred-myelin oligodendrocyte glycoprotein (MOG35-50)-specific CD4+ T cells proliferated in cervical lymph nodes and migrated to the CNS, suggesting that MHV infection in the CNS induces the activation of self-reactive T cells which are controlled by regulatory T cells to reduce the risk of developing inflammatory CNS disease. |
| Databáze: | OpenAIRE |
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