Circulating plasmacytoid dendritic cells in patients with primary and Helicobacter pylori-associated immune thrombocytopenia
| Autor: | Akio Saito, Morio Sawamura, Yoshiyuki Ogawa, Hiromi Koiso, Hirokazu Murakami, Takeki Mitsui, Hirotaka Nakahashi, Masamitsu Karasawa, Yoshihisa Nojima, Hiroshi Handa, Kohtaro Toyama, Yohei Osaki, Yoko Hashimoto, Akihiko Yokohama, Norifumi Tsukamoto, Hideki Uchiumi, Takayuki Saitoh |
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| Rok vydání: | 2012 |
| Předmět: |
Cellular immunity
Myeloid medicine.diagnostic_test hemic and immune systems Hematology General Medicine Biology Helicobacter pylori Natural killer T cell biology.organism_classification Flow cytometry medicine.anatomical_structure Immune system Antigen hemic and lymphatic diseases Immunology medicine biology.protein Antibody |
| Zdroj: | European Journal of Haematology. 88:340-349 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2011.01745.x |
| Popis: | Objectives: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the production of autoreactive antibodies against platelet antigens. Although dysfunction of multiple aspects of cellular immunity is considered to be important in the pathogenesis of ITP, it has not been clarified which cell types play a principal role. Methods: We enrolled 46 untreated patients with chronic ITP and 47 healthy adult volunteers, and investigated by flow cytometry the percentage and absolute number of cells in their peripheral blood that participate in the regulation of cellular immunity. These included plasmacytoid dendritic cells (pDCs), myeloid dendritic cells (mDCs), natural killer (NK) cells, natural killer T (NKT) cells, regulatory T (Treg) cells, and Th17 cells. Results: We found a significant reduction in the absolute number of pDCs, but not of mDCs, in patients with ITP when compared with healthy controls (P |
| Databáze: | OpenAIRE |
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