In VitroAntiparasitic Activity of Plant Extracts from Panama
| Autor: | Susana Muelas, José Antonio Escario, Cristina Fernández, Celeste Vega, P. N. Solís, David Montero, Juan José Nogal, A. Gómez Barrio, M. M. Martinez Grueiro, Miriam Rolón, Mahabir P. Gupta, A. R. Martinez Fernandez |
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| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
biology Antiparasitic medicine.drug_class Acid phosphatase Pharmaceutical Science Clusiaceae General Medicine biology.organism_classification medicine.disease_cause Microbiology Complementary and alternative medicine parasitic diseases Drug Discovery Botany biology.protein medicine Molecular Medicine Bixaceae Trichomonas vaginalis Anthelmintic Heligmosomoides polygyrus Trypanosoma cruzi medicine.drug |
| Zdroj: | Pharmaceutical Biology. 42:332-337 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200490511945 |
| Popis: | As a contribution to the search of antiparasitic activity in plants from Panama, a total of 37 extracts obtained from 14 species were assessed against Trypanosoma cruzi (Trypanosomatidae), Trichomonas vaginalis (Trichomonadidae), and Heligmosomoides polygyrus (Heligmosomidae). Also, the cytotoxicity to macrophages was determined, in order to discard, among the active extracts, those cytotoxic to mammalian cells. Tripanocidal activity and cytotoxicity to macrophages were performed by a colorimetric method using the tetrazolium salt MTT, assays on T. vaginalis by counting viable protozoa, and the anthelmintic activity was determined by enzymatic assays of acetylcholinesterase and acid phosphatase activities. Extracts from Bixa orellana L. (Bixaceae) and Clusia rosea Jacy. (Clusiaceae) were the most interesting both as antiprotozoan and nematocides. |
| Databáze: | OpenAIRE |
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