Immune Response in Guinea Pigs to Two Different Lipid Conjugates of Bovine Serum Albumin

Autor:	Suraj B. Singh, Sidney Leskowitz
Rok vydání:	1978
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 120:734-738
ISSN:	1550-6606 0022-1767
Popis:	A lipid conjugate of BSA was made by coupling dodecylamine to the COOH groups of BSA (DA-BSA). Studies on the immunogenicity of this material and one made by coupling dodecanoic anhydride to NH2 groups (D-BSA) demonstrated that cell-mediated immunity could preferentially be generated by lipid conjugation to an antigen as measured by delayed skin reaction, in vitro blast transformation, and antibody formation. DA-BSA was found superior by both in vivo and in vitro tests. Both the conjugates retained the ability to suppress delayed type hypersensitivity, but only DA-BSA retained the ability to elicit optimum skin reaction in a sensitized animals and to precipitate anti-BSA antibody.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef40e3ab709fd5668271109058e0fe9a https://doi.org/10.4049/jimmunol.120.3.734 Zobrazit plný text záznamu