Spectroscopic and anticancer studies on new synthesized copper(II) and manganese(II) complexes with 1,2,4-triazines thiosemicarbazide
| Autor: | M. S. El-Garib, Ibrahim M. El-Deen, Moamen S. Refat, W. Abd El-Fattah |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Russian Journal of General Chemistry. 85:692-707 |
| ISSN: | 1608-3350 1070-3632 |
| Popis: | Binuclear Cu(II) and Mn(II) newly transition metal complexes of the 5-benzylidene-3-(4-chlorophenyl)-6-oxo-5,6-dihydro-1H-[1,2,4]triazine-2-carbothioic acid amide (HL1) and 5-(3-bromo-4-methoxybenzylidene)-3-(4-chloro-phenyl)-6-oxo-5,6-dihydro-1H-[1,2,4]triazine-2-carbothioic acid amide (HL2) derived from the condensation of oxazolinone with thiosemicarbazide have been prepared. The structural elucidation was discussed upon elemental analyses and molar conductivity, as well as from mass, 1H NMR, IR, UV-Vis spectral studies. From the analytical, spectroscopic and thermal data, the stoichiometry of the mentioned complexes was found to be 1: 2 (metal: ligand). The molar conductance data revealed that all the metal chelates are non-electrolytes and the sulphato ions existing inside of the coordination sphere. The thermal stabilities of these complexes were studied by thermogravimetric (TG-DTG/DTA) and the decomposition steps of these complexes are investigated. The kinetic thermodynamic parameters such as the energy of activation (E*), pre-exponential factor (A), activation entropy (ΔS*), activation enthalpy (ΔH*) and free energy of activation (ΔG*) have been calculated. Inhibitory activity against breast carcinoma cells (MCF-7 cell line), hepatocellular carcinoma cells (HePG-2 cell line) and colon carcinoma cells (HCT cell line) were tested by using different concentrations of the samples (50, 25, 12.5, 6.25, 3.125, and 1.56 μg) and cell viability (%) was determined by colorimetric method. The drug doxrubcin was used as standard. |
| Databáze: | OpenAIRE |
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