ChemInform Abstract: A New Enantioselective Synthesis of β-Amino Acids

Autor:	W. Roy Jackson, Dilek Saylik, Andrea J. Robinson, Andrew Craig Donohue, Eva M. Campi
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Chemistry organic chemicals Enantioselective synthesis Substituent General Medicine Method development Amino acid Catalysis Chiral column chromatography chemistry.chemical_compound Organic chemistry heterocyclic compounds Enantiomer
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200131035
Popis:	Enantioselective hydrogenation of some α,β-unsaturated nitriles and their corresponding methyl esters bearing a phthalimidomethyl substituent at the α-carbon using Rh-DuPHOS catalysts afforded β-amino acid precursors with modest e.e.s of up to 48%. Hydrogenation of the α,β-unsaturated methyl esters using a Ru-BINAP catalyst gave higher e.e.s of up to 84%. Method development for the determination of the enantiomeric excesses of these derivatives using chiral HPLC is also reported.
Databáze:	OpenAIRE
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