Head and Neck Cancers: Why Is It Better to HPV than Not to HPV?
| Autor: | Michael S. W. Lee, Phil Wilson, Juan Carlos Kaski, Ingrid E. Dumitriu, Paramita Baruah |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty biology Angiogenesis business.industry VEGF receptors Healthy subjects Tumor tissue Vascular endothelial growth factor Tumor Status chemistry.chemical_compound Otorhinolaryngology chemistry Internal medicine biology.protein medicine Surgery Endostatin Head and neck business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 151 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599814541627a89 |
| Popis: | Objectives:Dissect the impact of human papillomavirus (HPV) on angiogenesis in head and neck cancers (HNSCC).Methods:We analyzed 18 newly diagnosed HNSCC patients and controls. HPV tumor status was ascertained by p16 staining. Eleven pro- and anti-angiogenic factors were quantified in sera using a multiplex assay. Angiogenic factors were analyzed in the tumor tissue using immunohistochemistry.Results:We found that circulating levels of anti-angiogenic factor endostatin were higher in all HNSCC patients compared with healthy subjects irrespective of HPV status. Notably, we detected higher levels of the proangiogenic factors angiopoetin-1 and vascular endothelial growth factor (VEGF) in the circulation of HPV-negative patients compared with patients with HPV-positive tumors. Interestingly, levels of thrombospondin-2, an antiangiogenic factor, were lower in the circulation of patients with HPV-positive compared with HPV-negative tumors and healthy controls. We next analyzed these angiogenic factors in the tu... |
| Databáze: | OpenAIRE |
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