Effect of UFT against oral cancers. Clinical effect and concentration of drug in tumor tissue
| Autor: | Hideyuki Hoshina, Yasushi Ohashi, Hidemori Mizutani, Yuji Nakayama, Norio Takahashi |
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| Rok vydání: | 1986 |
| Předmět: | |
| Zdroj: | Japanese Journal of Oral & Maxillofacial Surgery. 32:2071-2077 |
| ISSN: | 2186-1579 0021-5163 |
| DOI: | 10.5794/jjoms.32.2071 |
| Popis: | Antitumor effect of UFT against human oral and maxillary cancers was examined clinically and biochemically. UFT therapy was carried out in 26 patients having primary or recurrent tumors in a daily dose of 300-600mg. The average period was 132.1 days and the average dose was 71.4g. UFT therapy was combined with operation and/or radiotherapy in 20 cases, and 6 cases were treated for adjuvant chemotherapy.In preoperative administration, clinical response was observed in one case out of 5 evaluable cases (20%). When UFT therapy was combined with radiotherapy in five cases, tumors were diminished completely in every case. The survival rate of 24 cases was 76.5% in 30 months in those to whom UFT was administered for 4 weeks or more.5-FU levels in the serum and the tumor tissues were examined in 4 cases. 5-FU levels in the tumor tissues were 0.081-0.166 mcg/g and these were reached 6-27 times of the serum one.Side effects were observed in 8 cases (30.8%), mainly digestive symptom, bone marrow supression and liver disfunction. However, these were generally mild, only in 2 cases administration of UFT was stopped due to the side effects.It is considered that UFT can be administered to oral cancer patients usefully and safely. |
| Databáze: | OpenAIRE |
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