Novozym 435-catalyzed kinetic resolution of β-allenols. A facile route for the preparation of optically active β-allenols or allenyl acetates

Autor:	Zuyi Li, Shengming Ma, Daiwang Xu, Zhan Lu
Rok vydání:	2004
Předmět:	Novozym 435 Chemistry Organic Chemistry Drug Discovery Organic chemistry Stereoselectivity Optically active Solvent effects Biochemistry Kinetic resolution Catalysis
Zdroj:	Tetrahedron. 60:11879-11887
ISSN:	0040-4020
Popis:	A variety of optically active β-allenols and β-allenyl acetates were synthesized via the Novozym 435-mediated kinetic resolution of racemic β-allenols. A dramatic solvent effect was observed for the stereoselectivity. The scope of the substrates and the effect of the concentration and temperature on the reaction were also investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef25140c1c9285cc333121565915f613 https://doi.org/10.1016/j.tet.2004.09.103 Zobrazit plný text záznamu Full Text from ScienceDirect