Biokinetic modelling development and analysis of arsenic dissolution into the gastrointestinal tract using SAAM II

Autor: Yasmin Mohd Idris Perama, Khoo Kok Siong Kok Siong
Rok vydání: 2018
Předmět:
Zdroj: AIP Conference Proceedings.
ISSN: 0094-243X
Popis: A mathematical model comprising 8 compartments were designed to describe the kinetic dissolution of arsenic (As) from water leach purification (WLP) waste samples ingested into the gastrointestinal system. A totally reengineered software system named Simulation, Analysis and Modelling II (SAAM II) was employed to aid in the experimental design and data analysis. As a powerful tool that creates, simulate and analyze data accurately and rapidly, SAAM II computationally creates a system of ordinary differential equations according to the specified compartmental model structure and simulates the solutions based upon the parameter and model inputs provided. The experimental design of in vitro DIN approach was applied to create an artificial gastric and gastrointestinal fluids. These synthetic fluids assay were produced to determine the concentrations of As ingested into the gastrointestinal tract. The model outputs were created based upon the experimental inputs and the recommended fractional transfer rates pa...
Databáze: OpenAIRE