Rh(iii)-Catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes

Autor:	Bolin Zhu, Chen Chen, Zhuo Wang, Dianxue Ma, Shaonan Wu
Rok vydání:	2020
Předmět:	Indazole chemistry.chemical_compound chemistry Organic Chemistry Pyridine Surface modification Medicinal chemistry Divergent synthesis Catalysis
Zdroj:	Organic Chemistry Frontiers. 7:1158-1163
ISSN:	2052-4129
DOI:	10.1039/d0qo00248h
Popis:	We described a Rh(III)-catalyzed and solvent-controlled C–H bond functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes, which provided a straightforward way for the divergent synthesis of either C–H alkenylation products or indazole products in moderate to good yields. Control experiments were conducted, and a mechanism involving the rollover intermediates was proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef1bb182d00959b40467671ee421a3ec https://doi.org/10.1039/d0qo00248h Zobrazit plný text záznamu