L’endométriose est-elle une lésion pré-cancéreuse ? Perspectives et implications cliniques
| Autor: | K. Le Bail-Carval, G. Mellier, Gautier Chene, E. Beaufils, J. Caloone, P. Chabert, Gery Lamblin, S. Moret |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Gynecology
medicine.medical_specialty 030219 obstetrics & reproductive medicine endocrine system diseases ARID1A business.industry Endometriosis Obstetrics and Gynecology General Medicine medicine.disease female genital diseases and pregnancy complications Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Reproductive Medicine 030220 oncology & carcinogenesis medicine Cancer research Clear-cell ovarian carcinoma Ovarian cancer business Clear cell PI3K/AKT/mTOR pathway Fallopian tube |
| Zdroj: | Gynécologie Obstétrique & Fertilité. 44:106-112 |
| ISSN: | 1297-9589 |
| DOI: | 10.1016/j.gyobfe.2016.01.001 |
| Popis: | Epidemiological studies have shown a relationship between endometriosis and clear cell/endometrioid ovarian cancers (named "Endometriosis Associated Ovarian Cancer" or EAOC). The recent discovery of signaling pathways (especially the SWI/SNF and PI3K/AKT/mTOR pathways) that linked endometriosis and EAOC could lead to the development of specific biomarkers as ARID1A to screen benign to premalignant endometriosis and to new targeted treatment. Moreover, the better understanding of the pathogenesis of the epithelial ovarian cancer arising from the Fallopian tube could allow new early prevention strategies that will be described in this review. |
| Databáze: | OpenAIRE |
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