Wpływ testosteronowej terapii zastępczej na stężenia witaminy D i FGF-23 w hipogonadyzmie wrodzonym
| Autor: | Aydogan Aydogdu, Kamil Baskoy, Mahmut Ilker Yilmaz, Alper Sonmez, Omer Azal, Coskun Meric, Yalcin Basaran, Cem Haymana, Abdullah Taslipinar, Serkan Tapan |
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| Rok vydání: | 2017 |
| Předmět: |
Fibroblast growth factor 23
medicine.medical_specialty education.field_of_study business.industry Endocrinology Diabetes and Metabolism Population Osteoporosis 030209 endocrinology & metabolism medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance chemistry Internal medicine Homeostatic model assessment Vitamin D and neurology Medicine 030212 general & internal medicine business education Asymmetric dimethylarginine Hypogonadotrophic hypogonadism |
| Zdroj: | Endokrynologia Polska. 68:311-616 |
| ISSN: | 2299-8306 0423-104X |
| DOI: | 10.5603/ep.a2017.0009 |
| Popis: | Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases and osteoporosis. Vitamin D and Fibroblast growth factor-23 (FGF-23) play role in the regulation of bone mineral metabolism and endothelial functions. Low vitamin D levels are reported in hypogonadism, while there is no data about the effect of testosterone replacement therapy (TRT). We investigated the effect of TRT on vitamin D and FGF-23 levels along with endothelial functions and insulin resistance in hypogonadal patients. Material and methods: Patients with congenital hypogonadotrophic hypogonadism (CHH) (n=32, age 20.6 ±1.58 years) were enrolled. TRT was implemented in transdermal form. The demographic parameters, FGF-23, 25(OH)D3, Asymmetric dimethylarginine (ADMA) and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured both before and after TRT. Results: After a follow-up period of 3.63±1.33 months, ADMA and FGF-23 levels were significantly increased (p=0.03 and p=0.005 respectively), while the 25(OH)D3 and HOMA-IR index were not significantly changed. The body mass index and waist circumference levels of the patients were also increased (p |
| Databáze: | OpenAIRE |
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