Identification and analytical properties of acetyl fentanyl metabolites

Autor:	O. N. Dvorskaya, A. B. Melent’ev, S. S. Kataev
Rok vydání:	2015
Předmět:	Chromatography medicine.drug_class Atmospheric-pressure chemical ionization Mass spectrometry High-performance liquid chromatography Analytical Chemistry Hydroxylation Designer drug chemistry.chemical_compound Biotransformation chemistry medicine Organic chemistry Moiety Gas chromatography
Zdroj:	Journal of Analytical Chemistry. 70:240-248
ISSN:	1608-3199 1061-9348
Popis:	Acetyl fentanyl is a novel designer drug substance, a derivative of fentanyl. Its major metabolites were identified in samples of urine from consumers of acetyl fentanyl using gas chromatography and high-performance liquid chromatography with mass spectrometry detection. Structures of metabolites were proposed and confirmed by their fragmentation on electron impact and atmospheric pressure chemical ionization. The mass spectral and chromatographic properties of some derivatives of acetyl fentanyl metabolites were determined. The main path of the biotransformation of acetyl fentanyl is the hydroxylation of the phenylethyl moiety in the molecule.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ef0c210437ba151e42cc6bb461732adb https://doi.org/10.1134/s1061934815020124 Zobrazit plný text záznamu Plný text ve formátu PDF