Amelioration of Rhabdomyolysis-Induced Acute Kidney Injury by Ademetionine
| Autor: | V. M. Drachuk, Tetiana Shchudrova, T. G. Kopchuk, O. M. Goroshko, I. I. Zamorskii |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Kidney 030102 biochemistry & molecular biology urogenital system business.industry Glutathione peroxidase Biophysics Acute kidney injury Diuresis Pharmacology Protein degradation medicine.disease food.food 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure food chemistry medicine Azotemia Ademetionine business Rhabdomyolysis |
| Zdroj: | Biophysics. 64:799-803 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350919050257 |
| Popis: | —Using the animal model of rhabdomyolysis-induced acute kidney injury have revealed a significant nephroprotective effect of ademetionine by ability to eliminate the toxic action of myoglobin, manifested by an increase in diuresis, and glomerular filtration rate, a reduction of retention azotemia and proteinuria, the normalization of ion-regulating kidney function, an activation of the glomerular–tubular and tubular–tubular balances, and an improvement energy supply to the kidneys. A significant antioxidant effect of ademetionine has been confirmed with evidence that catalase and glutathione peroxidase activities were increased in kidney tissue with a significant decrease in lipid peroxidation and protein degradation. A cytoprotective efficacy was proven due to a decrease in gamma glutamyl transpeptidase activity in the urine of experimental animals. |
| Databáze: | OpenAIRE |
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