Synthesis of Novel Amino Acids Containing Cubane
| Autor: | Jonathan W. Burton, Robert D. M. Davies, Joanna Wlochal |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Synlett. 27:919-923 |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0035-1561502 |
| Popis: | The synthesis of four novel cubane-containing amino acids/protected amino acids is reported. Cubane glycine 5 was prepared, from readily available intermediate 9 . Cubane alanine 6 was prepared after developing conditions for the hydrogenation of unsaturated precursor 16 . Two further β-amino acids were prepared employing a Mitsunobu C–C bond-forming reaction and the addition of a lithium amide to an α,β-unsaturated ketone. |
| Databáze: | OpenAIRE |
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