Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy
| Autor: | Estrelita Janse van Rensburg, Karin Louise Richter, Sonja C. Boy, Willie F. P. van Heerden |
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| Rok vydání: | 2008 |
| Předmět: |
Gynecology
Cancer Research medicine.medical_specialty biology business.industry virus diseases medicine.disease biology.organism_classification female genital diseases and pregnancy complications Pathology and Forensic Medicine medicine.anatomical_structure Otorhinolaryngology Acquired immunodeficiency syndrome (AIDS) medicine Periodontics Papilloma Sex organ Viral disease Oral Surgery Oral mucosa Sida business Viral load Cervix |
| Zdroj: | Journal of Oral Pathology & Medicine. 37:555-559 |
| ISSN: | 0904-2512 |
| Popis: | BACKGROUND: To evaluate the prevalence of human papilloma virus (HPV) infection and types in the oral and cervix mucosa of treatment-naive HIV-1-positive women with CD4 counts less than 300 cells per ml with no HPV-associated oral lesions. METHODS: Oral epithelium was harvested from the buccal mucosa and lateral borders of the tongue and cervical samples were collected from the endocervical area of 30 women 22-64 years old. Cytobrush Plus cell collectors were used for sampling both anatomical areas. Genital pathology obstetric and gynaecological history co-morbid disease hormone therapy sexual behavior and smoking history were assessed via physical examination and clinical interviews. Special investigations included cervical Papanicolau smears CD4 counts and HIV-1 viral loads. The linear array HPV test was used to determine HPV genotypes present in the specimens. RESULTS: Oral HPV were identified in 20% (n = 6) of the patients of which two had infection with two HPV types. Genital HPV was found in 96.7% (n = 29) of the women of which only 14 had cytological abnormalities on Papanicolau smear. Infection with multiple HPV types were present in 93.1% (n = 27) of the patients with an average of four HPV types per individual. CONCLUSIONS: South African HIV-positive women with CD4 counts less than 300 cells per ml have a significant risk of cervical HPV strains and multiple strain infection of the cervix. The prevalence of HPV in normal oral mucosa was low but high-risk types were present. Limited correlation between oral HPV types and those identified in the cervical mucosa was found. |
| Databáze: | OpenAIRE |
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