Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis
| Autor: | Jiejun Cheng, Feng Zhang, Ye Yu, Liao-Yi Lin, Huawei Wu, Yi-Cheng Fu, Daoqiang Tang |
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| Rok vydání: | 2021 |
| Předmět: |
Lung
Receiver operating characteristic Tumor hypoxia business.industry Chemistry medicine.medical_treatment Venous phase Hypoxia (medical) Radiation therapy medicine.anatomical_structure medicine Radiology Nuclear Medicine and imaging Texture (crystalline) medicine.symptom Nuclear medicine business Arterial phase |
| Zdroj: | Japanese Journal of Radiology. 40:289-297 |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-021-01208-3 |
| Popis: | Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis. Twenty-five VX2 lung transplant tumors of twenty-two rabbits were included in the study. Contrast-enhanced spectral CT scanning in the arterial phase (AP) and venous phase (VP) was performed. Tumors were divided into strong and weak hypoxic groups by hypoxic probe staining results. Spectral CT image-related parameters [70 keV CT value, normalized iodine concentration (NIC), slope of spectral HU curve (λHU)] were measured and the texture analysis on the monochromatic images was performed. Imaging parameters and texture features between tumors with different hypoxic degrees were compared and their diagnostic efficacies for predicting hypoxia in lung cancers were analyzed using receiver operating characteristic (ROC) curve. NIC in VP and λHU in VP of the strong hypoxic group were significantly higher than those in the weak hypoxic group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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