Cu-mediated 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles: a faster access to spirooxindoles of potential pharmacological interest

Autor:	Shambhu Nath Singh, Girdhar Singh Deora, Manojit Pal, Abir Kumar Paul, K. Venkateshwara Reddy, Mohosin Layek, Sridhar Regati, Soumita Mukherjee, Sarva Jayaprakash
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Amide Isatin Organic Chemistry Drug Discovery 1 3-Dipolar cycloaddition Functional group Biochemistry
Zdroj:	Tetrahedron Letters. 54:5448-5452
ISSN:	0040-4039
Popis:	CuI facilitated three-component reaction of isatin derivatives, l-proline and terminal alkynes containing an amide or ester functional group. The multi-component reaction (MCR) afforded a faster and practical synthesis of spirooxindole derivatives. A range of novel spirooxindoles were synthesized by using this straightforward and one-pot efficient methodology. A representative compound showed significant inhibition of PDE4B enzyme in vitro and good interactions with this protein in silico.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eecc4fee9b6f2e413f173884c9d7c2fc https://doi.org/10.1016/j.tetlet.2013.07.126 Zobrazit plný text záznamu Full Text from ScienceDirect