Prognostic Value of Pulsed Tissue Doppler Imaging for the Assessment of Left Ventricular Systolic Function in Patients with Nonischemic Dilated Cardiomyopathy
| Autor: | Anca Simioniuc, Giacinta Guarini, Vitantonio Di Bello, Tommaso Gistri, Paolo Fontanive, Frank Lloyd Dini, Piercarlo Ballo, Mario Marzilli |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
business.industry Hazard ratio Dilated cardiomyopathy Dilative cardiomyopathy Systolic function medicine.disease Doppler imaging Heart failure Internal medicine medicine Cardiology Population study Radiology Nuclear Medicine and imaging In patient Cardiology and Cardiovascular Medicine business |
| Zdroj: | Echocardiography. 29:291-297 |
| ISSN: | 0742-2822 |
| DOI: | 10.1111/j.1540-8175.2011.01561.x |
| Popis: | There is still some debate regarding the prognostic significance of left ventricular longitudinal systolic dysfunction as assessed by tissue Doppler (TD) imaging in patients with chronic heart failure (HF), since previous studies have included patients with postischemic wall motion abnormalities. Thus, this study was designed to ascertain whether TD-derived longitudinal systolic dysfunction may influence the outcome of patients with nonischemic chronic HF. In 200 consecutive patients with chronic HF secondary to dilated cardiomyopathy and no history of ischemic heart disease, peak systolic mitral annular velocity (Sm) was measured by pulsed TD at the septal and lateral annular sites. The end points were cardiac death or hospitalization for worsening HF. Mean follow-up duration was 30 months. In a time independent analysis, averaged Sm calculated as the average of septal and lateral Sm, resulted to be a significant predictor of outcome in the study population (area under receiver–operator characteristic curve: cardiovascular death, 0.69, P < 0.0001; cardiovascular events, 0.64, P = 0.0005). In a time-dependent analysis, average Sm was associated with both cardiovascular death (hazard ratio 0.832, P = 0.0019) and cardiovascular events (hazard ratio 0.904, P = 0.039), independently of other clinical risk factors and echocardiographic parameters of systolic function. Septal Sm but not lateral Sm was independently associated with the outcome measures. In conclusion, the assessment of systolic mitral annular velocity by pulsed TD is a useful indicator for prognostic stratification of patients with nonischemic dilated cardiomyopathy and chronic HF. (Echocardiography 2012;29:291-297) |
| Databáze: | OpenAIRE |
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