Azino-Fused Benzimidazolium Salts as DNA Intercalating Agents. 2

Autor:	Jorge G. Siro, M. Melia Rodrigo, Beatriz de Pascual-Teresa, and Manuel Pastor, Juan J. Vaquero, Joaquín Pastor, Julio Alvarez-Builla, José L. García-Navío, Federico Gago
Rok vydání:	1997
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrocarbon Molecular model chemistry Organic Chemistry Intercalation (chemistry) Cationic polymerization Organic chemistry Moiety Spectroscopy Combinatorial chemistry DNA
Zdroj:	The Journal of Organic Chemistry. 62:5476-5483
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo962055i
Popis:	The synthesis of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts by basic condensation of 1,3-disubstituted 2-alkylbenzimidazolium salts and 1,2-diketones and subsequent chemical transformations is described. The DNA-binding properties were examined by UV-vis spectroscopy, viscosimetric determinations, and molecular modeling techniques. The presence of a flat polycyclic hydrocarbon moiety such as a naphthalene-1,8-diyl or a biphenyl-o,o'-diyl, fused to the cationic heterocycle, appears to enhance the interaction with DNA. Variation of the substituents on the indole-like N will allow us to build up a new series of bis-salts with bis-intercalating properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eebf963a0010fb6d0e5ab8d10478e6a1 https://doi.org/10.1021/jo962055i Zobrazit plný text záznamu