TRPs and Ca2+ in cell death and survival
| Autor: | Valerio Farfariello, Natalia Prevarskaya, Ingrid Fliniaux, Emmanuelle Germain |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Programmed cell death Physiology Autophagy Cell Biology Biology Cell fate determination Cell biology Divalent 03 medical and health sciences Transient receptor potential channel 030104 developmental biology chemistry Apoptosis Molecular Biology Cellular localization Intracellular |
| Zdroj: | Cell Calcium. 69:4-18 |
| ISSN: | 0143-4160 |
| DOI: | 10.1016/j.ceca.2017.07.002 |
| Popis: | Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to environmental stimuli. Pharmacological or genetic manipulations of TRP channels demonstrate that TRP channels influence cell death rates, prolonging or shortening of cell survival. Due to their diverse cellular localization, TRP channels mediated Ca2+ influx generates distinct intracellular Ca2+ signals that regulate downstream pathways converging to apoptosis or survival. In this review, we summarize the accumulated knowledge focused on how TRP channel regulate cell fate and may affect different pathologies including cardiovascular, neurological, metabolic or neoplastic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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