Synthetic approaches to macromolecular models for ion channel proteins

Autor:	Farzana Azam, Christine M. Bladon
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Sequence (biology) Peptide Biochemistry chemistry.chemical_compound Thioether chemistry Bromide Drug Discovery Moiety Chemical ligation Cysteine Macromolecule
Zdroj:	Tetrahedron Letters. 39:6377-6380
ISSN:	0040-4039
Popis:	The synthesis of a branched peptide is described using a ligation strategy to couple two peptides one of which is fully deprotected while the other is in a protected form. The ligation step involves formation of a thioether bond by using the thiol of a cysteine on the deprotected sequence to displace bromide from a bromoacetyl moiety on the second peptide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eea745389c91ebc6e7cc7452d3222c54 https://doi.org/10.1016/s0040-4039(98)01313-6 Zobrazit plný text záznamu Full Text from ScienceDirect