G protein-coupled odorant receptors: From sequence to structure

Autor:	Serge Antonczak, Jérôme Golebiowski, William A. Goddard, Soo-Kyung Kim, Claire A. de March
Rok vydání:	2015
Předmět:	Protein structure Subfamily Molecular model G protein Computational biology Binding site Biology Bioinformatics Molecular Biology Biochemistry Peptide sequence Conserved sequence G protein-coupled receptor
Zdroj:	Protein Science. 24:1543-1548
ISSN:	0961-8368
Popis:	Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G protein recognition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eea526481f0e7e41cdcf185fb27cac80 https://doi.org/10.1002/pro.2717 Zobrazit plný text záznamu Plný text