Association of IGF‐1 and IGFBP‐3 levels with gastric cancer: A systematic review and meta‐analysis

Autor:	Teck Yew Low, Hongyu Liu, Huxia Gu, Chong Zhang, Shing Cheng Tan, Emad H. Kutbi
Rok vydání:	2021
Předmět:	medicine.medical_specialty business.industry Healthy subjects Cancer Subgroup analysis General Medicine medicine.disease Gastroenterology Weighted mean difference Sample size determination Meta-analysis Internal medicine Healthy control medicine business Systematic search
Zdroj:	International Journal of Clinical Practice. 75
ISSN:	1742-1241 1368-5031
DOI:	10.1111/ijcp.14764
Popis:	PURPOSE Many studies have investigated the association between serum IGF-1 and IGFBP levels with gastric cancer (GC), but the results remained inconclusive. In this work, we performed a systematic review and meta-analysis to examine the precise association of serum levels of IGF-1 and IGFBP with GC. METHODS A comprehensive systematic search was carried out in PubMed/MEDLINE, SCOPUS, Web of Science, and EMBASE databases for (nested) case-control studies that reported the levels of IGF-1 and IGFBP in GC cases and healthy controls, from inception until October 2020. Weighted mean difference (WMD) was calculated for estimating combined effect size. Subgroup analysis was performed to identify the source of heterogeneity among studies. RESULTS We found eight and five eligible studies (with 1541 participants) which provided data for IGF-1 and IGFBP, respectively. All studies on IGFBP reported the IGFBP-3 isoform. The pooled results indicate that GC patients had significantly lower serum IGF-1 [WMD = -26.21 ng/mL (95% CI, -45.58 to -6.85; P = .008)] and IGFBP-3 [WMD = -0.41 ng/mL (95% CI, -0.80 to -0.01; P = .04; I2 = 89.9%; P
Databáze:	OpenAIRE
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