Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB1R) Antagonist

Autor: Yong Sok Lee, Nathan J. Coffey, George Kunos, Jie Liu, Sergio A. Hassan, Ziyi Liu, Robert B. Innis, Charles N. Zawatsky, Tony Jourdan, Grzegorz Godlewski, Malliga R. Iyer, Resat Cinar, Jeih-San Liow, Jaroslawna Meister, Jürgen Wess, Henry L. Puhl
Rok vydání: 2021
Předmět:
Zdroj: ACS Pharmacology & Translational Science. 4:1175-1187
ISSN: 2575-9108
Popis: Seven-transmembrane receptors signal via G-protein- and β-arrestin-dependent pathways. We describe a peripheral CB1R antagonist (MRI-1891) highly biased toward inhibiting CB1R-induced β-arrestin-2 ...
Databáze: OpenAIRE